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KMID : 0381120130350040463
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Genes and Genomics
2013 Volume.35 No. 4 p.463 ~ p.473
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Evolution of plant Ash1 SET genes: structural divergence and functional differentiation
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Zhu Xinyu
Wang Baohua
Kan Xianzhao
Chen Caoyi
Yu Chunmei
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Abstract
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Plant Ash1 SET proteins are involved in H3K36 methylation, and play a key role in plant reproductive development. Genes encoding Ash1 SET proteins constitute a multigene family in which the copy number varies among plant species and functional divergence appears to have occurred repeatedly. To investigate the evolutionary history and functional differentiation of the Ash1 SET gene family, we made a comprehensive evolutionary analysis of this gene family from eleven major representatives of green plants. A novel deep sister relationship grouping previously resolved II-1 and II-2 orthologous groups was identified. The absence of AWS domain in the group II-2 suggests that the independent losses of AWS domain have occurred during evolution. A diversity of gene structures in plant Ash1 SET gene family have been presented since the divergence of Physcomitrella patens (moss) from the other land plants. A small proportion of codons in SET domain regions were detected to be under positive selection along the branches ancestral to land plant and angiosperms, which may have allowed changes of substrate specificity among different evolutionary groups while maintaining the primary function of SET domains. Our predictive subcellular localization and comparative anatomical meta-expression analyses can assort with the structural divergences of Ash1 SET proteins.
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KEYWORD
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Ash1 SET genes, Evolution, Functional differentiation, Land plants, Structural divergence
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